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Information × Registration Number 0220U100254, 0118U003770 , R & D reports Title The study of bystander effect, induced by in vitro irradiated leukemic cells of patients with chronic lymphocytic leukemia, and possible of its modification by astaxanthin popup.stage_title Head Пілінська Марія Андріївна, Registration Date 14-01-2020 Organization State Institution «National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine» popup.description2  Objeсt: human peripheral blood lymphoсytes (HPBL). Purpose: to investigate the frequency of chromosome aberrations, the markers of DNA damage and the level of apoptosis in HPBL of conditionally healthy individuals under joint cultivation with blood cells of patients with chronic lymphocytic leukemia (CLL) irradiated in vitro at a dose of 0.50 Gy. Methods: cytogenetic (G0 sensitivity assay), molecular genetic (Comet assay). Results: the features of the development both the direct (classic) and reverse (rescue) bystander response phenomena due to the interaction between intact normal HLPCs of conditionally healthy individuals (bystander cells) and irradiated in vitro malignant blood cells of CLL patients (inducer cells) were established. Product Description popup.authors Eremeeva Mariya M. Demchenko Olena M. Dybska Olena B. Kravchenko Serhii M. Kurinnyi Denys A. Talan Oksana O. Shemetun Olena V. Sholoiko Valentyna V. popup.nrat_date 2020-04-02 Close