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Information × Registration Number 0220U100259, 0119U101613 , R & D reports Title Genetic markers that measure effectiveness DNA repair under the influence of occupational factors popup.stage_title Head Kundiiev Yurii I., Registration Date 14-01-2020 Organization State Institution "Kundiiev Institute of Occupational Health of National Academy of Medical Sciences of Ukraine" popup.description2  A scientific novelty of the study was to determine on the role of polymorphic variants of genes of various DNA repair systems in the mechanisms of formation of occupationally-related bronchopulmonary pathology among workers of main professions in the coal mining and asbestos-processing industry of Ukraine. For the first time, a spectrum of isolated genetic markers of DNA repair and their combinations, which are predictors of the risk of development of pathological processes, has been defined: minor homozygotes C/C•XPD (rs13181) OR=2.20; RR=2.23; 95%CI 1.02-4.77; P=0.020, χ2=4.85; A/A•XRCC1 (rs25487) OR=3.37; RR=3.34; 95%CI 1.22-9.63, P=0.008, χ2=6.94; and T/T•ATM (rs664677) OR=2.48; RR=2.46; 95%CI 1.16-5.31; P=0.010; χ2=6.61; as well as the heterozygote A/G (OR=2.32; RR=2.31; 95%CI 1.29-4.21; P=0.002; χ2=9.01) and the minor allele G•MLH1 (rs1799977), (OR=1.61; RR=1,61; 95%CI 1.04-2.49; P=0.020; χ2=5.06). Markers with a protective function include: a heterozygote for G/A•XRCC1 (rs25487) OR=0.57; RR=0.57; 95%CI 0.32-1.02; P=0.040, χ2=4.14; a dominant allele A (OR=0.62; RR=0.62; 95%CI 0.40-0.96, P=0.020, χ2=5.06) and a dominant homozygote A/A•MLH1 (rs1799977), (OR=0.43; RR=0.44; 95%CI 0.24-0.79, P=0.003, χ2=8.73). The presence of synergistic high power interactions between polymorphisms is established: XPD (rs13181)→ATM (rs664677) 2.15%; ERCC1 (rs11615)→ATM (rs664677) 1.82%; and antagonistic interactions of significant power between polymorphisms: XPD (rs13181)→XRCC1 (rs25487) -1.70%; XRCC1 (rs25487)→ATM (rs664677) -2.22% and ATM (rs664677)→MLH1 (rs1799977) -1.75%, which affect the risk of formation of bronchopulmonary pathology taken into account in the development of pathways of the personalized approach to risk minimization. Product Description popup.authors Andrushchenko Tetyana A. Kundiiev Yurii I. popup.nrat_date 2020-04-02 Close