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Information × Registration Number 0220U100271, 0119U101473 , R & D reports Title Study of hormonal and metabolic pathways of parathyroid disorders in survivors exposed to ionizing radiation as a result of the Chornobyl accident popup.stage_title Head Kaminskyi Oleksii V., Доктор медичних наук Registration Date 14-01-2020 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2  Study object: retrospective evaluation of clinical data on the effects of ionizing radiation on endocrine system in the 40 survivors of the Chornobyl accident and 40 of their descendants compared with the general population data (20 children and 20 adults). Ultrasound imaging data on 1534 survivors and 185 controls were evaluated, as well as on 187 of their descendants and 63 children of the control group to detect the parathyroid hyperplasia. Objective of the study: to determine the status of parathyroid glands in persons exposed to Chernobyl accident in adulthood and childhood. Research methods: generally accepted clinical, anthropometric (body weight, height, hip volume, body mass index), instrumental (thyroid and parathyroid ultrasound examination), laboratory (biochemical, hormonal) data, statistical. High frequency of parathyroid hyperplasia was detected in persons irradiated as a result of the Chernobyl disaster, primarily in evacuees from the 30 km exclusion zone (71.4 %; p = 0) and residents of radioactively contaminated territories (41.7 %; p ≤ 0, 01), without primary hyperparathyroidism. The incidence of hyperparathyroidism, predominantly secondary one, was 33.8% among those exposed to the Chernobyl accident (p ≥ 0.3) being slightly higher than in the general population of Ukraine (26.1%). Possible positive relationship was established between vitamin D and free thyroxine (r = 0.729; p = 0.001), negative - with thyroid-stimulating hormone (r = -0.803; p = 0.001) in the Chornobyl accident survivors, indicating a direct relationship between hypothyroidism and vitamin D deficiency. The hypothalamic-pituitary-thyroid system dysfunction was found in the 55.3% of children born to parents irradiated as a result of the Chernobyl disaster. There is a more frequent manifestation of parathyroid hyperplasia (ultrasound imaging data) in children born from residents of radioactively contaminated territories, namely - 42.6 % versus 29.3 % in the group of children born Product Description popup.authors Afanasyev Dmytro E. Kaminskyi Oleksii V. Kopylova Olga V. Muraviova Iryna M. Tepla Olena V. Chykalova Iгyna G. popup.nrat_date 2020-04-02 Close