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Information × Registration Number 0220U100290, 0119U101178 , R & D reports Title Study of the effectiveness and safety of the use of gold nanoparticles in thermal burns popup.stage_title Head Volkova Natalia O., Кандидат біологічних наук Registration Date 15-01-2020 Organization Institute of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine popup.description2  The results of the study indicate that for 21 days the use of MG with AuNPs at concentrations of 1.5 to 6 μg/ml contributed to the activation of regenerative processes in burn wounds, which had a manifestation in increasing the rate of reduction of burn area, restoration of histological structure of the skin, normalization of leukocyte content and total protein in the blood. Analysis of the results of immunohistochemical studies showed that in the groups with application of MG with AuNPs the areas positively stained for vimentin, pan-keratin, cadherin and desmin, and the ratio of collagen type I / III exceeded the corresponding values in the control. The application of MG to the wound with AuNPs did not affect the expression level of the epithelial markers p63, CKAP4 and SMARCE1. Comparative analysis of the dynamics of wound healing in the study groups showed that burn wounds recovered faster in the case of MG with AuNPs at a concentration of 6 μg / ml. Product Description popup.authors Volkova Natalia O. Goltsev Anatoliy M. Ostankov Maksym V. Ostankova Liudmyla V. Pavlovych Olena V. Sokil Larysa V. Yukhta Maria S. popup.nrat_date 2020-04-02 Close