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Information × Registration Number 0220U100291, 0115U001533 , R & D reports Title Biosafety and efficiency of interaction of inert metals nanoparticles with mesenchymal stem cells of the bone marrow popup.stage_title Head Goltsev Anatoliy M., Доктор медичних наук Registration Date 15-01-2020 Organization Institute of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine popup.description2  The use of gold, silver and platinum nanoparticles at concentrations up to 6 μg/ml does not lead to changes in bone marrow MSСs phenotype, morphology, colony formation, proliferation, mitochondrial activity, type I collagen synthesis, expression of cytokeratins, vimintines and p-53. The use of gold, silver and platinum nanoparticles at concentrations of 10 μg/ml exerts a toxic effect on bone marrow MSCs, which is manifested in the reduction of colony formation, proliferative and mitochondrial activity, the level of collagen I type synthesis, the change in the receptor profile and the increase in the percentage of necrotic cells. Product Description popup.authors Budnyk Oksana P. Volkova Natalia O. Goltsev Anatoliy M. Pavlovych Olena V. Sydorenko Mykhailo V. Sokil Larysa V. Fesenko Olena M. Yastrebova Olena V. popup.nrat_date 2020-04-02 Close