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Information × Registration Number 0220U100613, 0119U100331 , R & D reports Title Newest hybrid anti-tumor and anti-inflammatory nanocomplexes based on pyrrole and C60-fullerene: creation, characterization, pharmacodynamics and toxicological characteristics. popup.stage_title Head Rybalchenko Volodymyr K., Доктор біологічних наук Registration Date 22-01-2020 Organization Taras Shevchenko National University of Kyiv popup.description2 Object of study: nanocomplex based on C60 fullerene and MI-1. Subject of study: physicochemical properties, pharmacological activity, toxicity of C60 fullerene-based nanocomplex and 1- (4-chlorobenzyl) -3-chloro-4- (trifluoromethyl-phenylamino) -1H-pyrrole-2,5-dione nanocomplex ( MI-1). Purpose - development, synthesis and characterization of complex nanostructure based on C60 fullerene and MI-1, its establishment antiproliferative activity and general toxicity. Research methods: chemical synthesis, spectroscopic, NMR, elemental and spectral analysis, atomic force microscopy, dynamic light scattering, scanning tunneling microscopy, homologous modeling, molecular docking, quantum-chemical method of molecular orbitals, histological, histological, histological, statistical . Based on the analysis of potential biological efficiency (antiproliferative activity, non-toxicity, ability to interact with growth factor receptors) and economic feasibility, the most promising compound based on C60 fullerene and pyrrole derivative 3 - {[4-chloro-1- (4-chlorobenzyl) -2 , 5-dioxo-2,5-dihydro-1H-pyrrol-3-yl] amino} phenyl [6,6] -phenyl-C61-butanoate (C60-MI-3OH), which has been synthesized and characterized by physico-chemical methods. The ability of C60-MI-3OH to inhibit the growth of neoplastic cell lines to predict its in vivo toxicity and potential biological activity was analyzed.  Product Description popup.authors Bielinska Iryna V. Dzubenko Natalya V. Zolotarenko Anatoliy D. Zolotarenko Oleksandr D. Kuznezova Galyna M. Milokhov Demyd S. Prylutska Svitlana V. Repetsky Stanislav P. Rybalchenko Volodymyr K. Stoika Rostislav S. Khilya Olga V. Zyvinska Svitlana M. Chereschyuk Iryna O. popup.nrat_date 2020-04-02 Close