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Information × Registration Number 0220U100704, 0118U001714 , R & D reports Title To determine the peculiarities of chemical and radiation factors genotoxic influence on radiotherapy cytogenetic effects in cancer patients in vivo and ex vivo popup.stage_title Head Maznyk Nataliia O., д.б.н. Registration Date 24-01-2020 Organization State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine" popup.description2 Object of study: cytogenetic effects in cultured peripheral blood lymphocytes of cancer patients various tumor localizations during therapeutic exposure. The aim: to assess the effect of previous chemoradiotherapy on the character of radiation- and chemical-induced cytogenetic effects during radiation therapy in vivo and ex vivo depending on the mutagenic factor and tumor localizations. Research methods and techniques: cytogenetic analysis of human blood cultured lymphocytes, statistical methods of data processing, microscopes Axioskop, Micros MC300X, Olympus CX41 and Olympus, system ASIS. Theoretical and practical results: The different pace of chromosome aberrations accumulation in groups of patients with various tumor localizations was found. The increase of radiation-induced aberrations from beginning to end of the first part of treatment before scheduled radiotherapy break in patients with lung cancer and less pronounced changes in these parameters in patients with head and neck tumors were demonstrated. Undergone the second part of the course of radiotherapy the range of chromosome aberrations in patients with head and neck tumors did not expand. These data are of importance for correct assessing the impact of therapeutic irradiation on the chromosomal level. Novelty: the quantitative yield and quality range of cytogenetic damage in lymphocytes of patients with lung cancer and head and neck cancer before and during radiation therapy in the presence of a break following exposure were identified. The effectiveness of implementation: methodological approach of the study was implemented in institute’s radiology department practice; 3 articles, 5 abstracts were published, 4 presentations made. Area of application: radiobiology, radiation therapy, radiation medicine.  Product Description popup.authors Artiukh Serhii V. Bilozor Nataliia V. Haiseniuk Larysa O. Hukova Inna M. Dashkova Svitlana A. Kolpakova Liudmyla K. Maznyk Nataliia O. Myrna Olha M. Niemykina Nadiia V. Pshyshevska Liudmyla A. Sviatenko Nina I. Sypko Tetiana S. Slobodianiuk Olha V. Starenkyi Viktor P. popup.nrat_date 2020-04-02 Close