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Information × Registration Number 0220U100802, 0115U004620 , R & D reports Title "To develop methods of targeted synthesis of nanocomposites based on modified polysaccharides and functionalized with folate has and research their toxic and selective action on cancer cells for use in cancer therapy" popup.stage_title Head Estrela-Lopys Viktorio R., Registration Date 28-01-2020 Organization F. D. Ovcharenko Institute of Biocolloidal Chemistry NAS of Ukraine popup.description2 As a result of the performed research, the methods of synthesis of selenium nanoparticles, its modification by adsorption layer of Chlorella microalgae polysaccharides and the functionalization of such bioconjugate of calcium folate (NHSePSFa) or antibiotic doxorubicin (NoxSubecinSD) were developed. The physicochemical characteristics of such composites, their stability in phys. blood solutions and plasma. The intensity of aggregation of the obtained bioconjugates with blood cancer cells and prostate adenocarcinoma cells was also investigated, and the selectivity of such aggregation was found for cancer cells (compared to conditionally healthy human lymphocytes).  Product Description popup.authors popup.nrat_date 2020-04-02 Close