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Information × Registration Number 0220U100962, 0119U100631 , R & D reports Title Research contribution of the system inflammation, oxidative processes and the most wide-spread persistent infection in development of comorbid conditions of the persons who were affected by Chornobyl accident popup.stage_title Head Ovsiannikova Liudmyla M., Доктор медичних наукChumak Anatolii A., Доктор медичних наук Registration Date 30-01-2020 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2 The object of the study was the metabolic and immune processes involved in the development of chronic inflammatory response and impaired pro-antioxidant balance in pathological conditions in individuals who have been exposed to damaging environmental factors. The purpose of the work was to evaluate changes in individual biochemical and immunological parameters in the comorbid course of chronic diseases of the hepatobiliary zone, cardiovascular system and / or dyscirculatory pathology of the brain in persons affected by the Chernobyl accident. Methods of research  general clinical examination, instrumental studies (US of abdominal organs, esophagogastroduodenoscopy), biochemical, immunological, statistical, informational-analytical. The analysis of changes of individual biochemical and immunological parameters to determine the feasibility of their application in assessing the contribution of systemic inflammation, oxidative processes and most common persistent infections in the development of comorbidity of the victims due to the Chernobyl accident, in particular at the time of chronic disease, and / or dyscirculatory pathology of the brain. The manifestations of inflammatory reactions, disorders of lipid and carbohydrate metabolism, signs of cytolytic and cholestatic syndromes were diagnosed. Most patients were at risk of developing complicated cardiovascular pathology. Activation of the processes of lipoperoxidation with the accumulation of secondary TBARS was observed in the majority of patients in each risk groups, which was accompanied by the accumulation of proteins oxidative modification products., Mixed infection of herpes simplex virus types 1 and 2 (anti-HSV-1/2 IgG) and / or cytomegalovirus (anti-CMV IgG) and / or Epstein-Barr virus (anti-EBV IgG) was observed in most seropositive patients. The highest antibody titers to herpes simplex virus type 1 and type 2 and the Epstein-Barr virus nuclear antigen were reported in low-risk seropositive patients. Product Description popup.authors Aliokhina Svitlana M. Kadiuk Olena M. Nosach Olena V. Ovsiannikova Liudmyla M. Pleskach Oksana Ya. Sarkisova Eleonora O. Chumak Anatolii A. Shyiko Tetiana O. popup.nrat_date 2020-04-02 Close