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Registration Number

0220U101186, 0116U004393 , R & D reports

Title

Definition of hepatoprotective properties of pharmaceutical composition based on katiazyn - stimulator of spermatogenesis

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Head

Kudria Mariia Ya., Кандидат біологічних наук

Registration Date

05-02-2020

Organization

State Institution “V.Ya.Danilevsky Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine”

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 Object: pharmaceutical composition based on cathazine, functional and metabolic state of the liver, spermatogenesis. Objective: To study the effect of a catiazine-based pharmaceutical composition on the functional state of the liver under conditions of simulation of hepatitis of different genesis. Methods: pharmacological, biochemical, physiological, hemostatic, organic synthesis, spectral, pharmaceutical, statistic. The composition and technology of the combined dosage form of cathazine in the form of solid gelatin capsules are theoretically and experimentally substantiated.Methods of qualitative analysis and quantitative determination of pharmaceutical composition components have been developed. Models of subacute tetrachloromethane and paracetamol-induced hepatitis in male rats have been reproduced to investigate the corrective effect of a cathiazine-based pharmaceutical composition on impaired liver function and spermatogenesis. The results of the study indicate a positive effect of the pharmaceutical composition with cathazine on the functional state of the liver and the testes in terms of their pathology.

Product Description

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2020-04-02