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Information × Registration Number 0220U101227, 0119U101242 , R & D reports Title Development and implementation of predictive miRNAs panel for personalized design of neoadjuvant therapy for breast cancer patients popup.stage_title Head Lukianova Nataliia Yu., Registration Date 05-01-2020 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  The profile of circulating miR-21, -155, -182, -373, -125b, -126, -199a, -200b, -205, -375, associated with the main clinical and pathological characteristics of breast cancer of different molecular subtypes was established. The connection of miRNAs levels with stage, presence of metastases in regional lymph nodes and tumor differentiation degree was determined. The relationship between circulating miRNAs expression with the sensitivity of breast cancer of different molecular subtypes to standard regimens of neoadjuvant chemotherapy and the overall and relapse-free survival rates of patients who received line I and II therapy has been established. Basing on the obtained data, we designed the innovative prognostic and predictive panels to assess the tumors’ sensitivity to neoadjuvant chemotherapy and the risk of breast cancer recurrence, which will significantly improve the treatment outcomes and breast cancer patients’ quality of life. The results were introducted into clinical practice of the Kyiv City Clinical Oncology Center and the Clinic of Personalized Design of Diagnostics and Therapy "Oncotheranostics" according to the information sheets "Method of determining the sensitivity to neoadjuvant platinum-containing polychemotherapy in patients with triple-negative cancer." / V.F. Chekhun, Yu.V. Dumansky, N.Yu. Lukianova, I.V. Shepelenko, T.V. Borikun, V.M. Bazas, T.M. Yalovenko // Kyiv. - 2019. - No. 248), "Method for determining the sensitivity to neoadjuvant polychemotherapy in breast cancer patients with a basal molecular subtype of tumors ”(Informational Journal / V.F. Chekhun, Yu.V. Dumansky, N.Yu. Lukianova, I.V. Shepelenko, T.V. Borikun, V.M. Bazas, T.M. Yalovenko // Kyiv - Ministry of Health of Ukraine - 2019 - No. 249 and "Method for predicting sensitivity to neoadjuvant chemotherapy by anthracycline-containing regimens in patients with breast cancer of luminal A and B subtypes" (Newsletter / NY Lukianovа, V.F. Chekhun, I.V. Shepelenko, T.V. Borikun, O. Product Description popup.authors Borikun Tetiana V. Lukianova Nataliia Yu. Сhekhun Vasyl F. Shepelenko Iryna V. popup.nrat_date 2020-04-02 Close