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Information × Registration Number 0220U101256, 0116U007262 , R & D reports Title To investigate the role adypokines in the development of cardiovascular complications in patients with type 2 diabetes with nonalcoholic fatty liver disease popup.stage_title Head Kravchun Nonna O., Доктор медичних наук Registration Date 07-02-2020 Organization State Institution “V.Ya.Danilevsky Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine” popup.description2 Object: metabolic, immunological, hormonal status of patients with type 2 diabetes mellitus with non-alcoholic fatty liver disease (NAFLD). Aim: to study the role of adipokines in mechanisms of development of cardiovascular complications in patients with type 2 diabetes with NAFLD. Methods: clinical, biochemical, immunological, statistical. Weight gain is accompanied by an increase in NOMA, FFA, and leptin index, which correlate positively with fractalkine, clusterin, vaspin, and vice versa with omentin.Patients with type 2 diabetes mellitus with NAFLD have a direct relationship between adiponectin and TG, which indicates the progression of atherogenic dyslipidemia with decreasing adiponectin levels. A direct relationship was found between resistin levels and IL-1β and IL-6. Resistin unidirectionally correlates with some lipid fractions, confirming its role in atherogenesis. Hyperhomocysteinemia can be considered a marker of fibrotic changes in liver tissue and a marker of cardiovascular risk.Against the background of dapagliflazine and metformin therapy, a decrease in BMI, non-invasive liver fibrosis, improvement in carbohydrate and lipid metabolism were detected. Average levels of leptin in patients with type 2 diabetes with NAFLD increased. No statistically significant contribution of the single-nucleotide polymorphism G-2548A of the LEP gene to the formation of susceptibility to the development of type 2 diabetes.  Product Description popup.authors popup.nrat_date 2020-04-02 Close