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Information × Registration Number 0220U101282, 0117U003926 , R & D reports Title The molecular-genetic and morphological features of tissue regeneration of the lower limb under conditions of chronic hyperglycemia popup.stage_title Head Tymoshenko Oleksii O., Registration Date 07-02-2020 Organization Sumy State University popup.description2  The genotyping of the Ukrainian population has been performed - the patients with diabetic foot syndrome and the individuals of control group by polymorphic loci rs1044498, rs997509, rs3025039, rs1800247 of the genes ENPP1, VEGF-A and BGLAP. It has been found the rs1044498-polymorphism association of ENPP1 gene with the diabetic foot syndrome development: in the carriers of the minor Q-allele the risk of this pathology is 1.9 times higher than in the homozygotes of the main K-allele. The association of ENPP1 gene rs997509-polymorphism with the risk of diabetic foot syndrome has been established in the obese individuals. It has been shown that the minor T-allele increases the risk of developing this complication by 9.7 times in patients with obesity. No association was found between polymorphic loci of VEGF-A and BGLAP genes with the development of diabetic foot syndrome in the Ukrainian population. The features of regeneration of rat hind limb tissues under conditions of chronic hyperglycemia were investigated at an ultramicroscopic level. It has been found that post-traumatic recovery of skeletal muscle of rats with chronic hyperglycemia is characterized by the incomplete myogenesis, the overdeveloping of connective tissue, the disorder of the new blood vessels formation and the decreasing of the number and area of regenerating muscle fibers. Product Description popup.authors Harbuzova Yelizaveta A. Hodovas Daria V. Danylenko Maryna I. Dudchenko Yevhenii S. Kirian Valentyna O. Maksymova Olena S. Muravskyi Dmytro V. Mchedlishvili Nazar S. Udovenko Vadym M. Chumachenko Yaroslav D. popup.nrat_date 2020-04-02 Close