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Information × Registration Number 0220U101642, 0119U101980 , R & D reports Title Search for new antimalarial drugs aimed at disrupting the functioning of the tubulin apparatus of plasmodium popup.stage_title Head Karpov Pavlo A., Кандидат біологічних наук Registration Date 17-02-2020 Organization Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine popup.description2  Studies have been conducted to confirm the complete identity of the sites and the mechanism of binding of dinitroaniline / phosphorothiamidate derivatives on the surface of all isotopes of Plasmodium α-tubulin molecules officially registered in the Republic of India. The alanine scan method determines that the amino acid residues Arg2, Val250, Glu3, Asp251 and Glu254 play a key role in the binding of the above compounds. Selected structural proteins that can be used to further create fluorescence structures for the purpose of lifelong study of cytoskeletal anomalies under the influence of dinitroaniline and phosphorothioamide derivatives. Product Description popup.authors Yemets Alla I. Blume Yaroslav B. Demchuk Oleh M. Karpov Pavlo A. Ozheredov Sergey P. Rayevsky Olexey V. Spivak Svitlana I. popup.nrat_date 2020-04-02 Close