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Information × Registration Number 0220U101647, 0118U002207 , R & D reports Title Development of 2D materials and "smart" sensors for medical and biological purposes on their basis.Section 2. Synthesis of 2D materials based on BN and WS2 nanoparticles for biomedical applications popup.stage_title Head Posudievsky Oleg Yu., Registration Date 17-02-2020 Organization L. V. Pisarzhevskii Institute Of Physical Chemistry of The National Academy of Sciences of Ukraine popup.description2 It was shown the 2D hexagonal boron nitride (h-BN) modification possibility by amine and carbonyl groups through mechanochemical treatment of bulk h-BN with ammonium carbonate or heat treatment of mechanochemically nanostructured boron nitride (nh-BN) with subsequent ultrasound exfoliation in water. It was found that 2D nh-BN nanoparticles modification by amine and carbonyl groups to improve the stability of its dispersions in water. It was investigated the cytotoxicity of2D nanoparticles based on tungsten disulfide (WS2), molybdenum disulfide (MoS2), nhBN and its modified forms (nh-BNmod); it was tested invitro the ability of these nanoparticles to enhance cytotoxic action the traditional chemotherapeutic drug doxorubicin against cancer cells. It was established the dependence of the concentration test compound and duration of incubation cancer cells on its action; it was demonstrated that the combined use of 2D nanomaterials with doxorubicin did not reduce the cytotoxic effect of chemotherapeutic drug on cancer cells.  Product Description popup.authors popup.nrat_date 2020-04-02 Close