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Registration Number

0220U101686, 0119U102680 , R & D reports

Title

Investigation of the role of peroxisomes in metabolism and alcoholic fermentation of xylose and glycerol in the yeast Ogataea polymorpha

Head

Kurylenko Olena O., Кандидат біологічних наук

Registration Date

18-02-2020

Organization

Institute of Cell Biology

Description

 The role of gene AOX1, coding for alcohol oxidase, the key peroxisomal enzyme, on ethanol production during alcoholic fermentation was studied. The overexpression of AOX1 gene resulted in increased ethanol production from xylose and glycerol. The О. polymorpha pex3 mutant with impaired peroxisome biogenesis and pex11 mutant with impaired peroxisome division were constructed during the fulfillment of the project. The knockout of PEX11 gene in the genome of the wild-type strain resulted in 1.5-fold increased ethanol production from xylose, on the other hand the overexpression of PEX11 had no significant influence on ethanol production.

Product Description

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Vasylyshyn Roksolana V.
Semkiv Marta V.