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Information × Registration Number 0220U101832, 0117U002034 , R & D reports Title Molecular and biological factors of malignant cells heterogeneity and variability of clinical course of hormone dependent tumors popup.stage_title Head Chekhun Vasyl F., Доктор медичних наук Registration Date 26-02-2020 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  It was shown in vitro, that hyperinsulinemia, in the case of separate culturing of fibroblasts and MCF-7 BC cells, leads to increased fibroblast proliferation and a decrease in the number of living tumor cells. Insulin enhances glucose uptake by MCF-7 cells and fibroblasts or adipocytes when co-cultured. It has been shown in vivo that the growth of Walker-256 carcinosarcoma results in disruption of the prooxidant-antioxidant balance and changes in the content of essential elements related to glucose metabolism, and thus the formation of oxidative stress in animals. The redox state of the blood of patients with breast cancer varies depending on the age and hormone receptor status of the tumors and is associated with an increase in superoxide and NO-generating activity of neutrophils, elevated levels of NO-Hb, MetHb, quinones and ubisemiqinones, and gelatinase activity. An increase in CYP 1A2 levels in tumor cells correlates with elevated levels of the superoxide radical in the mitochondria, cell type, and disease stage. It has been determined that the expression of the chemokine receptor CXCR4 in patients with breast cancer depends on the molecular subtype of neoplasm, correlates with the expression of S18-2 and is associated with the density of microvessels in the tumor and the presence in patients of metabolic syndrome. The expression of EpCAM directly correlates with the stages of the tumor process and inversely - with the expression of the proliferation marker - Ki67. Conclusions. The studies conducted have revealed additional characteristics of tumor molecular subtypes and factors associated with metastasis and terminal stages of the tumor process, therefore, may indicate a risk of progression of breast cancer and should be taken into account when deciding on personalized treatment regimens as markers of disease progress and monitoring treatment effectiveness. Product Description popup.authors Ivanchenko Alina V. Burlaka Anatoliy P. Buchynska Lubov G. Karaman Olga M. Kovalevska Larysa M. Lykhova Olexandra O. Losovska Julia V. Makovetska Lyudmyla I. Naleskina Lesia A. Prokhorova Iryna V. Sarnatska Veronika V. Todor Igor M. Chekhun Vasyl F. popup.nrat_date 2020-04-02 Close