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Information × Registration Number 0220U101959, 0117U001414 , R & D reports Title Study of age-related morpho-functional features of cell components and histo-hematic barriers of several organs in experimental diabetes mellitus type I and II, and in some cases their correction popup.stage_title Head Kvitnytska-Ryzhova Tetiana Yu., Доктор медичних наук Registration Date 28-02-2020 Organization State institution "D. F. Chebotarev Institute of Gerontology National Academy of Medical Sciences of Ukraine" popup.description2 The results allow us to evaluate the morpho-functional changes of the pancreas, liver, myocardium, kidney and brain of animals of different ages in the modeling of insulin resistance (IR) and diabetes mellitus (DM) caused by alimentary obesity, as well as their correction by N-steroilethanolamine (NSE). The development of severe fatty liver was observed in the modeling of IP and CD, with higher levels of steatosis, destructive and apoptotic changes in old animals. Following NSE therapy, there was a significant reduction in liver fatty dystrophy and a certain normalization of its ultrastructure, especially in adult rats. Diabetic cardiomyopathy was observed in myocardial tissue with IR and DM, which was significantly deeper in older animals and decreased slightly with NSE. Therapeutic effects of NSE on CA1 zone of the hippocampus after the development of IR and DM: the number of vacuolated neurons in young animals decreased, and the number of gliocytes in old animals normalized. In general, in IR and DM older rats developed more pronounced destructive and dystrophic processes, as well as dramatically increased rates of apoptotic cell death. After the NSE therapeutic course, there was a stable tendency to improve structural parameters, first of all in the liver, which is better expressed in adult rats than in old rats. NSE activated compensatory changes: marked pancreatic islet hyperplasia; normalization of morphological parameters in the liver, kidney, to a lesser extent - in the myocardium.  Product Description popup.authors Klymenko Pavlo P Lugovskiy Sergiy P Malysheva Svitlana P Mykhalskyi Sergiy A Khablak Galyna V popup.nrat_date 2020-04-02 Close