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Registration Number

0220U101988, 0117U001416 , R & D reports

Title

The impact speed of the growth on the rate of aging and lifespan of Drosophila melanogaster (epigenetic programming rate of life)

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Head

Voitenko Volodymyr P,

Registration Date

28-02-2020

Organization

State institution "D. F. Chebotarev Institute of Gerontology National Academy of Medical Sciences of Ukraine"

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Life expectancy in different species correlates markedly with duration of their development. A hypothesis on the developmental origin of aging was proposed. If the special joint program for the development and aging really exists, then there would be possible to modulate viability, aging rate, and life expectancy of different organisms, including Drosophila melanogaster, through modulating the rate and duration of their development. In our research, the influence of various physical and chemical factors on the developmental stage on the rate of development and adult life expectancy of D. melanogaster has been studied. It has been demonstrated that the average duration of development of flies which developed in conditions of high larval density was greater (9 to 12 days) than in controls (8 days). Those insects that developed under "overcrowding" conditions, were characterized by a significant decrease in the average body weight of the imago compared to the control flies. In both males and females eclosed during first two days in high density conditions, both mean and maximum LSs were significantly increased, and in flies eclosed during subsequent days decreased in comparison to control. Based on the results obtained, we hypothesized that the development of D. melanogaster under conditions of high density at the larval stage (if the developmental duration is not too long) may produce a hormetic response that contributes to the prolongation of the life of these insects. Decreasing the temperature at the stage of development caused lengthening the development of Drosophila. The highest longevity was observed in flies developed at a temperature of 22.5 °C. The results are explained by the existence of a temperature optimum determining the potential for maximum life expectancy. Lowered rate of development was revealed in Drosophila, whose larval development took place at a low oxygen concentration. Deviation from the normal oxygen concentration during the larval develop 

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Ivanov Stephan H
Vaiserman Olexandr M
Denis Yevgen O
Zabuga Oksana H
Koshel Natalya M
Krasnenkov Dmytro S
Kukharskyy Vitaliy M
Mechova Ludmila V
Pisaruk Anatoliy V

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2020-04-02