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Information × Registration Number 0220U102135, 0117U001415 , R & D reports Title Age-related specifics of nitric oxide system in the pathogenesis of radiation-induced disturbances of regulation of body functions in aging:pilot testing of methods of correction popup.stage_title Head Gorban Evgen M., Доктор медичних наук Registration Date 09-03-2020 Organization State institution "D. F. Chebotarev Institute of Gerontology National Academy of Medical Sciences of Ukraine" popup.description2 Applied course feeding of Quartin 3 times a week for 2 weeks at the dose of 10 mg/kg per active substance one week after irradiation. The agonist- and insulin-dependent responses of vessels isolated in experimental animals (fragments of the thoracic aorta and mesenteric artery) were investigated in experiments with mechanographic recording of contractile reactions. Results: A single X-ray irradiation (7 Gy) of rats caused a disturbance in the regulation of vascular contractility, which occurred under the condition of excess production and deposition of NO in the endothelium and perivascular adipose tissue. Course administration of quercetin to irradiated rats led to a partial normalization of contractile and dilatory vascular responses. The therapeutic effect of quercetin was manifested by the reduction of NO accumulation in the endothelium and perivascular adipose tissue. The research results indicate the actuality of further finding a means of preventing the occurrence of negative radio-induced metabolic disorders, which may be promising for their prophylactic use.  Product Description popup.authors Parshikov Olexander V Povh Nina N Utko Nataliia O Skrimbal Olexander M popup.nrat_date 2020-04-02 Close