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Registration Number

0220U102153, 0117U001419 , R & D reports

Title

To study influence of Quercetinum on endogenous cardiovascular risk factors and aging biomarkers in elderly subjects with metabolic syndrom

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Head

Korkushko Oleg V, Доктор медичних наук

Registration Date

10-03-2020

Organization

State institution "D. F. Chebotarev Institute of Gerontology National Academy of Medical Sciences of Ukraine"

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То clarify the effectiveness of quercetin in reducing endogenous cardiovascular risk factors, the effect of quercetin on aging biomarkers and increasing hypoxia resistance, 110 elderly patients with metabolic syndrome were examined. The examined were divided equally into two groups - the main and the control. Patients of the main group took quercetin for 3 months (daily dose of quercetin 240 mg). Patients in the control group received a placebo over the same period. The course use of quercetin leads to a decrease in the manifestations of dyslipidemia (reduces the level of total cholesterol and low density cholesterol, atherogenicity index), leads to a normalizing effect on carbohydrate metabolism, improves the functional state of vascular endothelium, contributes to an additional hypotensive effect, reduces the indicators of spontaneous and induced platelet aggregation, blood viscosity, increases resistance to hypoxia, and also leads to an increase in telomere length. At the same time, in the control group during the observation of significant changes in indicators characterizing the various manifestations of the metabolic syndrome, did not occur. The results obtained indicate that quercetin has a complex beneficial effect on endogenous cardiovascular risk factors, increases hypoxia resistance and leads to an increase in telomere length. 

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Antonyuk-Scheglova Ivanna A
Bondarenko Olena V
Havalko Hanna V
Hryb Oksana M
Duzhak Georgiy V
Zabuga Oxana H
Krasnyenkov Dmytro S
Naskalova Svetlana S
Shatylo Valeriy B

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2020-04-02