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Information × Registration Number 0220U102183, 0118U102391 , R & D reports Title Investigation of the interaction of curcumin with cellular targets and the selection and creation of its functionally effective forms for the treatment of neurodegenerative diseases popup.stage_title Head Yemets Alla I., Доктор біологічних наук Registration Date 10-03-2020 Organization Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine popup.description2  Properties of liposomes based on soybean lecithin, egg yolk and sunflower seeds mixed with phospholipids were investigated by electron paramagnetic resonance spectroscopy. It is shown that the stability of liposomes from phospholipids of sunflower is associated with the presence of chlorogenic acid, which has antioxidant properties. For the model of Alzheimer's disease positive dynamics of anti-inflammatory effect of aqueous solution of curcumin in vitro at transcriptional and translational levels of cytokine formation by mononuclear cells were revealed, as well as its direct inhibitory effect on the level of endogenous Aβ40 under conditions of toxic action of exogenous Aβ42. According to the molecular docking and structural analysis of the complexes obtained, the most probable binding sites for curcumin derivatives are two β-tubulin surface sites, namely, a vinblastin binding site and a colchicine binding site. Product Description popup.authors Yemets Alla I. Andriyash Ganna S. Bayer Oleh O. Beiko Natalia Ye. Blume Yaroslav B. Horiunova Inna I. Demchuk Oleh M. Karpov Pavlo A. Kravets Olena A. Novozhilov Dmitry О. Ozheredov Sergey P. Pydiura Nikolay O. Plokhovska Svitlana H. Rayevsky Olexey V. Samofalova Dariya O. Spivak Svitlana I. Tigunova Helen O. Shulga Sergey M. popup.nrat_date 2020-04-02 Close