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Information × Registration Number 0220U102365, 0118U004274 , R & D reports Title Study of the prevalence, features of clinical manifestations, mechanisms of progress and development of the treatment approaches of nervous system affection in patients with diabetes mellitus, metabolic syndrome and obesity. popup.stage_title Head Mankovsky Boris M., Доктор медичних наук Registration Date 12-03-2020 Organization State Scientific Institution "Center for Innovative Medical Technologies of the NAS of Ukraine" popup.description2   At the secondary stage of the study, patients with newly type 2 diabetes mellitus (CD2) were examined in order to detect cognitive impairment, cardiac autonomic neuropathy, determine the level of hypoxia induction factor (HIF), brain neurotrophic factor (BDNF) level, and status pro- and antioxidant system. The exclusion criteria for the study were the history of TBI, stroke, occupational diseases, Parkinson's disease and other diseases that could affect the study and give false results, the presence of CD2 in the anamnesis, treatment with any antidiabetic drugs before. The aim of our work was to determine the effect of metformin on the state of cognitive function, hypoxia factor (HIF) level, brain neurotrophic factor (BDNF) level, as well as the status of the pro- and antioxidant system in patients with newly diagnosed type 2 diabetes. Purpose: to search for new alternative ways of timely diagnosis of diabetic neuropathy and to develop modern therapies. Research methods: general clinical - to determine the status of patients: collection of complaints and medical history, physical examination with measurement of anthropometric indicators (height, weight), establishment of body mass index; biochemical to assess lipid metabolism based on total cholesterol (TC), triglycerides (TG), carbohydrate metabolism as determined by glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG); psychometric tests: 5 word test, mental status assessment scale (MMSE), battery of frontal dysfunction tests (BPD), clock drawing test evaluation, Rey Audirory Verbal Lerning Test (RAVLT), Brixton test, Trail making test (TMT), Digit span forward and backforward (DSFB), Verbal fluency test (animal part) (FV), Test symbol (TS), Stroop color test (SCT); diagnosis of somatic-sensory diabetic neuropathy. Product Description popup.authors Zherdova Nadiia M Orlyk Olga S Saienko Ianina A Sakharova Yulia V popup.nrat_date 2020-04-01 Close