Search academic texts

Information × Registration Number 0220U102434, 0117U000478 , R & D reports Title Improvement of the methods of diagnosis of papillary thyroid carcinomas and prognosis of metastases development for choosing a tactics of their adequate treatment popup.stage_title Head Кваченюк Андрій Миколайович, Registration Date 13-03-2020 Organization STATE INSTITUTE "V.P. KOMISSARENKO INSTITUTE OF ENDOCRINOLOGY AND METABOLISM OF THE NATIONAL ACADEMY OF MEDICAL SCIENCE OF UKRAINE" popup.description2  Object: radioiodine-resistance of thyroid cancer as a onsequence of impraied of the expression of antigens and enzymes of thyrocytes, ultrasound, cytological, immunocytochemical, morphometric characteristics of papillary thyroid cancers and their radioiodine refractory metastases, pathological changes of the reproductive organs of patients with thyroid cancer in long-term observation. Purpose: determination of ultrasound, cytological, immunocytochemical features of radioiodine-resistant metastases of papillary thyroid cancer, development of software for automation of the basic stages of the algorithm for determining the level of asymmetry of cell nuclei on the material of puncture biopsies of thyroid neoplasms, assessment of the structure of the uterus, ovaries and breast and reproductive system disorders in patients after radioiodine therapy with long-term follow-up. Methods: ultrasound, cytological, immunocytochemical, morphometric, statistical. Studies have shown that ultrasound revealed metastatic lymph nodes of the neck allow for further immunocytochemical and cytological studies, which can increase the efficiency of diagnosis of metastases of differentiated thyroid cancer and to develop treatment tactics. A statistically significant difference in the expression of thyroid peroxidase and thyroglobulin in FNA smears of radioiodine-resistant and radioiodine-avid metastases of papillary thyroid cancer has been shown on the basis of which a new method of preoperative prediction of radioiodine resistance and efficacy of radioiodine therapy was developed. As a result of the work, the algorithm for preoperative prediction of radioiodine resistance of thyroid papillary carcinoma was first proposed, based on the detection of cytological and immunocytochemical features of thyrocytes in the FNA smears. Product Description popup.authors Bozhok Uriy M Gulevatyi Sergiy V. Zelinska Ganna V Kvachenuk Andriy M. Kuchmenko Tetyana M Shelkovoy Yevgen A popup.nrat_date 2020-04-01 Close