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Information × Registration Number 0220U102453, 0118U007343 , R & D reports Title Molecular, genetic and pharmacological agents of influence on cellular mechanisms of neurological disorders. popup.stage_title Head Kryshtal Oleg O., Доктор біологічних наук Registration Date 13-03-2020 Organization Bogomolets Institute of Physiology popup.description2  The absence of Calcium in extracellular space as well as calcium channels blocking lead to the development of non-synaptic epilepsy. The new phenomena revealed: the synchronization between the CA1 and CA3 zones of the hippocampus in the low-calcium environment. Blocking of nicotinic ACh-receptors eliminates or significantly reduces this type of synchronicity. It has been shown for the first time that the acetylcholine synaptic system can synchronize the electrical activity of the hippocampus in the absence of other synaptic systems activity. Pathological processes that occur in the rat brain during inflammation caused by the lipopolysaccharides model of Parkinson's disease reduce the likelihood of epileptic seizures. A decrease in the activity of ASIC channels leads to a decrease in both the dominant frequency of the θ rhythm and the overall level of locomotor activity in the open field test at a dose of 10 uM/kg, but not 1 uM/kg. NHE1 exchanger plays an essential role in proton-sensitive nociception by removing protons from the cell. NHE1 and other proteins involved in pH regulation can be targeted for the testing of new analgesics. Thapsigargin inhibits all ATPases in dose-dependent mode. Dyhitroartemizynin does not affect the ATPase activity of proteasomes. These results indicate the prospect of the described molecular mechanisms as targets in the development of the novel drugs. Product Description popup.authors Isayev Dmytro S. Maksymyuk Oleksandr P. Prudnikov Igor M. Storozhuk Maksum V. Cherninsky Andrij O. Chyzhmakov Ihor V. popup.nrat_date 2020-04-01 Close