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Information × Registration Number 0220U102476, 0117U002580 , R & D reports Title Early molecular genetic and immunohistochemical predicting of susceptibility to lung and digestive system cancer progression. popup.stage_title Head Tumanskyi Valerii O, Registration Date 16-03-2020 Organization Zaporizhzhya State Medical University popup.description2   For the first time in parallel molecular genetic (PCR-RF) and immunohistochemical studies Significant transcriptional alterations of genes and their encoded proteins have been identified, which are involved in the realization of the invasive potential of intestinal adenocarcinoma cells. Intracellular adhesion disorders begin Already at the non-invasive stage of intestinal adenocarcinoma, at the same time as abnormal KRAS activity and functionally related signaling cascades are maximally realized at the invasive stage of tumor development. There was a further development of the proposition that the progression of intestinal adenocarcinoma from the non-invasive to invasive stage of development is associated with an increase in apoptosis of cancer cells, a change in their immunophenotype on the intestinal, and with an increase in stromolytic activity of cancer and stromal cells. Advanced scientific concepts on the progression of gastric hyperplastic polyps, in which the leading role is played by dysplasia with an increase in the proliferative activity of epitheliocytes against the accumulation of p53 oncoprotein, the development of enterolysis, as well as increased expression of MMP-2 and TIMP-1 by epithelial and stromal cells. Product Description popup.authors Baudarbekova Meruert M Kabachenko Valeriia O Kovalenko Inna S Pyrohova Zoia O Khrystenko Tetiana O Shyshkin Maksym A popup.nrat_date 2020-04-01 Close