Search academic texts

Information × Registration Number 0220U102599, 0117U000408 , R & D reports Title To develop a radionuclide monitoring and diagnostic algorithm to detect recurrence and metastasis in patients with iodine-negative forms of differentiated thyroid cancer. popup.stage_title Head Solodiannykova Oksana I., Registration Date 09-04-2020 Organization National Cancer Institute popup.description2 Object of the study - 115 patients with iodine-negative metastases of the thyroid gland. The purpose of the work is to develop an algorithm for postoperative management of patients with iodine-negative metastases of differentiated thyroid cancer. Research Methods and Apparatus - Full body scintigraphy with 99mTc-MIBI; whole body scintigraphy with 99mTc-DMCA; x-ray computed tomography; 18F-FDG positron emission tomography; methods of statistical processing of results; two-detector gamma camera from Mediso (Hungary), single-photon emission computed tomograph (SPECT) "E. CAM 180". The study group consisted of 115 patients with iodine-negative metastases of the thyroid gland, of whom 30 patients underwent SVT with 99mTc-MIBI - 30, SVT with 99mTc-DMCA - 30, PET with 18F-FDG - 30, CT - 25. Ten patients with In addition, a complex scintigraphic study with 99mTc-pertechnetate was performed, which included dynamic and static scintigraphy to obtain angiographic curves with metastatic lesions of the thyroid gland. Comparative assessment of iodine-negative RFP, CT and PET / CT with 18F-FDG revealed the highest percentage of sensitivity and specificity of scintigraphic imaging for PET / CT with 18F-FDG, which were 92.8 ± 11.2 and 89.4 ± 9, 2 respectively. Creating and using the algorithm of postoperative management of patients with iodine-negative forms of thyroid cancer will allow timely detection of recurrences and metastases and to carry out appropriate treatment, namely surgical, radiation and target.  Product Description popup.authors Danylenko Viktoriia V. Dzhuzha Dmytro O. Kmetyuk Yaroslav V. Semeniv Іgor P. Sukach Georgii H. popup.nrat_date 2020-07-03 Close