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Information × Registration Number 0220U102619, 0119U000575 , R & D reports Title To develop a method of combined treatment of melanoma patients with metastatic lesion of regional lymph nodes popup.stage_title Head Korovin Serhiy I., Доктор медичних наук Registration Date 10-04-2020 Organization National Cancer Institute popup.description2 The method of treatment of patients with metachronous metastases of regional lymph nodes developed on the background of adjuvant interferon therapy with the use of dendritic cell autoscopy and the treatment of patients with synchronous and metachronous inflammation or metastatic lesions of more than three lymph nodes) using adjuvant radiotherapy and middle ozone interferon therapy. According to the developed and standard methods, 45 thematic patients with melanoma with metastases in regional lymph nodes were treated. Patients with metachronous metastases of melanoma in regional lymph nodes, arising on the background of low-dose interferon therapy (25 patients), after performing radical surgery in the volume of regional lymphodissection, depending on the results of randomization of the patient. cells derived from the patient's blood cells and activated tumor antigens). Patients with skin melanoma metastases in regional lymph nodes with unfavorable prognostic factors (20 patients), after performing radical surgery, received nonspecific immunotherapy with intermediate doses of interferon in combination with the results of randomization. Methods of treatment of patients with synchronous and metachronous metastases of skin melanoma in regional lymph nodes were developed, 45 patients were treated according to defined and standard methods and immediate results of treatment were evaluated. Satisfactory tolerability of immunotherapy of dendritic cell vaccine compared to interferon therapy was established; an increase in the number of AEs in the radiotherapy and interferon therapy group compared to interferon therapy. Product Description popup.authors Dyedkov Serhiy A Kukushkina Mariia M Kukushkina Mariia Nikolayevna Chornenʹkyy Denys O popup.nrat_date 2020-07-03 Close