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Information × Registration Number 0220U102737, 0115U003875 , R & D reports Title Reactivity of newborn's organs after antigens and factors of different orgin influence during introuterine period of development popup.stage_title Head Voloshyn Mykola A, Доктор медичних наук Registration Date 19-05-2020 Organization Zaporizhzhya State Medical University popup.description2  Using histological, morphometric, lectinhistochemical, immunohistochemical, and electron-microscopic research methods, the morphological features of rat liver after intrauterine administration of staphylococcal toxoid and dexamethasone were established. The data on the distribution of lymphocytes in the liver after intrauterine administration of staphylococcal toxoid and dexamethasone are supplemented. The distribution and dynamics of the content of dendritic cells in the liver of rats after intrauterine administration of staphylococcal toxoid and dexamethasone are described. The results of the thymus study expand modern ideas about the morphogenesis and structure of rat thymus in the postnatal period of development and complement the concept of Professor N.A. Voloshin about a lymphocyte as a factor of morphogenesis. It was revealed that after prenatal hormonal and antigenic effects, changes in the ratio of cortical and medullary substances occur due to the expansion of the subcapsular zone in early postnatal period and a decrease of the inner cortex during the first month of life. The idea about the prenatal effect of dexamethasone on the ratio of cells in the thymus is supplemented. Studying the thymus, it was found that after the administration of the hormone, an increase in the number of LCA + dendritic cells and the number of castor bean lectin receptors on lymphocytes in the first two weeks, as well as a decrease in the number of WGA + and CK5 / 14 + epithelial cells in the first month, and the number of peanut lectinreceptors on lymphocytes in the first 2 days of postnatal life take place. Data on the prenatal effects of staphylococcal toxoid on cell ratio has been expanded. When studying the thymus, it was shown that in antigen-primed rats there is an increase in the number of LCA + dendritic cells in the first three days of life. It was found that in rats after intrauterine administration of antigens, changes in the dynamics of meniscus morphogenesis are o Product Description popup.authors Abrosimov Yurii Yu Bohdanov Pavlo V. Hryhorieva Olena A Kovalchuk Kateryna S Korotchuk Yevhen V. Mamai Iryna Yu Cherniavskyi Artur V. popup.nrat_date 2020-07-03 Close