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Information × Registration Number 0220U102766, 0115U003877 , R & D reports Title Experimental detectuon of synthetic and natural substances with hypoglycemic, lipid-lowering, hepatoprotective, nephroprotective, deprimiruyushie, antioxidant and anti-iflammatory activity popup.stage_title Head Trzhetsynskyi Serhii D., Доктор біологічних наук Registration Date 25-05-2020 Organization Zaporizhzhya State Medical University popup.description2 Experimental studies of the hypoglycemic properties of a decoction of the underground organs of Poteriumsanguisorba L. indicate that the decoction has the ability to reduce the formation of insulin resistance and glucose intolerance against the background of keeping animals on a high-fat diet. The ability of the decoction of Poteriumsanguisorba L. to reduce the formation of abdominal-visceral obesity has been established. The antiradical activity of tincture of Portulacaoleracea herb was revealed. Experimental studies of water extract of Portulacaoleracea herb indicate that Portulacaoleracea herb infusion has the ability in rats to reduce the formation of insulin resistance and glucose intolerance against the background of a dexamethasone model of diabetes mellitus and a diet with a high fat content, can inhibit the formation of abdominal-visceral obesity, andits hypoglycemic activity can be compared with glyclazide and metformin. According to the results of a pharmacological study, a thick extract of grass and seed oil of camelina cultivar Slavutich at a dose of 200 mg/kg when administered orally for 14 days significantly inhibit the formation of glucose tolerance. According to the study of raw materials of Medicagofalcata L. subsp. romanica (Prodan) O.Schwarz & Klink. the presence of such substances as dihydrocoumarin, coumarin, benzyl alcohol, dihydroactinidiolide, palmitic acid, loliolide was revealed. By chromatography of an extract of the native dried yellow alfalfa raw material, 66 components were found, and 38 compounds were identified among them. Representatives of true coumarinswere identified among them: dihydrocoumarin (1,60%) and coumarin (13,13%). When conducting gas-liquid chromatography 52 components were found and 41 compounds were identified. The qualitative composition and quantitative content of amino acids, polysaccharide fractions, hydroxycinnamic acids, polyphenolic compounds, organic acids, lipophilic pigments in plant raw materials. Product Description popup.authors Grechana Olena V Denisenko Olga M Kinichenko Hanna O Korniievska Valentyna H Korniievskyi Yurii I Kulynych Roman L Mazulin Heorhii V Mozul Valentyna I Nosulenko Inna S Panchenko Svitlana V Tsykalo Tetiana O popup.nrat_date 2020-07-03 Close