Search academic texts

Information × Registration Number 0220U102914, 0115U002948 , R & D reports Title Identification of the low molecular metabolites in serum samples as a basis of test kits for diagnosis of ischemic brain damage and some neurodegenerative diseases popup.stage_title Head Korpan Yaroslav I., Кандидат біологічних наук Registration Date 23-06-2020 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2  Modeling of transient global cerebral ischemia in FVB mice was performed; assessment of regional cerebral blood flow in experimental animals in normal and in the simulation of transient global cerebral ischemia in mice of the FVB line; confocal-microscopic analysis of brain sections of experimental animals; statistical analysis of the obtained data; assessment of cognitive functions of experimental animals using a panel of behavioral tests; immunohistochemical analysis of frontal sections of the brain of experimental animals. The analysis of the content of low molecular weight serum metabolites in normal and after focal cerebral ischemia in mice, in the culture medium of rat hippocampal sections in the control and after simulation of ischemic injury in vitro, analysis of glucose, lactate, pyruvate, α-ketoglutorate, α-sectoglutarite and urea in the serum of patients who have suffered an ischemic stroke. It was found that the concentration of glucose after simulation of ischemic injury decreases by 1.5 times, and the concentration of L-lactate increases by 1.9 times. Product Description popup.authors Biloivan Olha Anatoliivna Zhybak Mykhailo T. popup.nrat_date 2020-07-03 Close