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Information × Registration Number 0220U102985, 0116U001721 , R & D reports Title The scientific basis of synthesis, reactivity and biological activity of nitrogen- and sulfur-containing heterocycles and quinoneimines popup.stage_title Head Kharchenko Oleksandr V., Доктор хімічних наук Registration Date 06-07-2020 Organization Ukrainian State University of Chemical Technology popup.description2  Object of the study – the synthesis of nitrogen and sulfur-containing heterocyclic compounds. The purpose of the work – development and implementation of synthesis methods for new heterocyclic compounds exhibiting high biological activity. Research methods - chemical synthesis, thin layer chromatography (TLC), X-ray diffraction analysis (PCA), infrared spectroscopy (IR) and nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry. Literary review and substantive preparative approaches to the synthesis of nitrogenous heterocycles have been performed. A method for the synthesis of benzothieno [2 ', 3': 4,5] pyrimido [1,6-b] [1,2,4] triazines has been proposed. A new method for the synthesis of 1,3,5-oxadiazine derivatives using dehydrosulfurizing reagents has been developed. A method for the synthesis of substituted 2- (1-acyl-3-phenyl-1H-pyrazol-5-yl) phenols has been developed.A method for the preparation of ethyl 2-amino-6,8-dimethyl-1,3-dioxo-1,2,3,4-tetrahydropyrrolo [1,2-a] pyrazine-7-carboxylate by intramolecular cyclization of N-substituted pyrroles has been found. Areas of application: C 21.10 manufacture of basic pharmaceutical products, C 20.20 manufacture of pesticides and other agrochemical products. Product Description popup.authors Bilov Volodymyr V. Varenychenko Svitlana A. Zadorozhnii Pavlo V. Zalizna Kateryna V. Karpishchenko Liudmyla S. Kyselov Vadym V. Kryshchyk Oksana V. Lomynoha Olena O. Markov Viktor I. Okhtina Oksana V. Paramonova Tetiana H. Kharchenko Oleksandr V. Yakymenko Ihor Yu. Yanova Karolina V. popup.nrat_date 2020-10-01 Close