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Registration Number

0220U103795, 0119U102174 , R & D reports

Title

The assessment еffects of radioprotectors under the joint action of radiation and cold stress

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Head

Krasnoselskyi Mykola V., Доктор медичних наук

Registration Date

19-11-2020

Organization

State Organization "Grigoriev Institute for Medical Radiologiy and Oncology of the National Academy of Medical Sciences of Ukraine"

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 Object of research: the effectiveness of S-heterylmodified thiol under the joint action of radiation and cold stress. Purpose: experimentally determine the features of the effects of radioprotectors (S-heteryl-modified thiols) under the joint action of radiation and cold stress. Methods: radiobiological, hematological, morphological, statistical. Equipment: CLINAC 6 MeV linear accelerator, UNIDOS universal dosimeter, automatic hematology analyzer RT-7600, microscope Leica 6000B, analytical balance. Theoretical and practical results: it was found in the experiment that a positive low temperature of 4± 2◦C (cold stress) significantly modified the radioprotective effect of S-heterylmodified thiol under acute irradiation (7.5 Gy) in animals depending on the type of individual reactivity. Under the introduction of a radioprotector, the most effective modifying effect of cold stress was manifested in hyporeactive animals in a decrease of lethality after irradiation by 3.0 times, the lengthening of the onset of diarrhea and bleeding by 1,3 and 1,1 times, the reduction in the time of the clinical course of radiation injury by 1,5 and 1,4 times. Under the joint action of cold stress and acute irradiation (7.5 Gy), the effectiveness of S-heterylmodified thiol in hyporeactive animals was manifested in a decrease of fall in the number of leukocytes by 1,3 times, platelets by 1,4 times, erythrocytes by 2,0 times and in accelerating the rate of growthing of the number of peripheral blood cells to the control level. Novelty: for the first time it was determined in a radiobiological experiment the effectiveness of S-heterylmodified thiol in animals with different types of individual reactivity to acute irradiation (7.5 Gy) under the joint action of cold stress. Use area: radiobiology.

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Zavhorodnii Ihor V
Kryvko Alevtyna I
Leonova Iryna O
Lytovchenko Olena V
Maslennikova Olena L
Neniukova Olena V
Pavlichenko Yuliana V.
Skorobogatova Nataliya G
Uzlenkova Nataliia Ye.

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2020-11-19