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Information × Registration Number 0220U103889, 0118U007344 , R & D reports Title Investigation of the participation of ion channels in intracellular signaling of the nervous system cells in norm and pathology popup.stage_title Head Lukianets Olena O, Registration Date 27-11-2020 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  Studies of the involvement of calcium and potassium channels in a number of brain pathologies have been conducted. Studies of calcium signaling in cerebellar neurons under hypoxic conditions have shown that cerebellar neurons are highly sensitive to hypoxic conditions, and their calcium overload can lead to their death. Investigation of the effect of β-amyloid (Ab) on the impulse activity of isolated neurons CA1 of the hippocampus. showed that Ab in individual cells increased impulses. Examining changes in intracellular calcium and its content in the endoplasmic reticulum of hippocampal neurons, in the simulation of Alzheimer's disease (HA), showed that amyloid Ab increased basal calcium levels in neurons almost twice. A study of the effect of cerium dioxide (NDC) nanoparticles on the culture of neurons in the hippocampus of rats with simulated HA disease showed that NDC significantly prevented cell death by protecting them from toxic Ab. A new experimental model of ex vivo acute stress has been proposed: direct patch clamp recording of the electrical activity of identified CRH neurons PVN in sections of the hypothalamus under the action of hypoglycemia. A study of the role of calmodulin in the desensitization of TRPV1 channels showed that the effect of its chlorpromazine antagonist is determined by an increase in the level of intracellular calcium, which depends on the increase in the concentration of calcium in the solution. Product Description popup.authors Bogdanova Natalia О. Burlak Mar"yana Р. Ganzha Vita V. Gorbachenko Vasyl А. Kravenska Ievgeniia V. Kravenska Eugenia V. Lukyanets Igor О. Lukyanets Olena О. Magura Igor S. Melnick Igor V. Petrushenko Mariya O. Petrushenko Olena A. Rozumna Nataliya M. Tarasenko Olexandr М. Tyshchenko Yuliya М. Chentsova Ilona I. Shkril Vyacheslav M. Yavorsky Volodymyr А. popup.nrat_date 2020-11-27 Close