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Information × Registration Number 0220U103959, 0116U004512 , R & D reports Title The influence of risk factors and invasive treatments on acute and chronic forms of ischemic heart disease popup.stage_title Head Kyiak Yulian H., Registration Date 02-12-2020 Organization Danylo Halytsky Lviv National Medical University popup.description2  It was found that the most common risk factors for coronary heart disease in patients with STEMI and NSTEMI are hypertension and dyslipidemia; at the same time at the majority of persons the combination of 3-4 factors of risk of coronary heart disease is revealed at once. Type 2 diabetes and smoking were more likely to cause NSTEMI. The presence of risk factors for coronary heart disease in patients with ACS such as type 2 diabetes, smoking and occupational hazards, leads to signs of calcification, hibernation, dystrophy and increased platelet adhesion, activation of their degeneration and apoptosis. With these ultrastructural changes, there is an increased risk of ACS and sudden death. In 50% of cases of NSTEMI and in 57.89% of cases of STEMI, in the presence of comorbid type 2 diabetes, multivascular lesions of CA were found, which was significantly more frequent compared to patients without diabetes (p<0.05). In addition, 58.33% and 52.38% of patients, respectively, had chronic occlusions of the CA, which was 29.17% and 21.05% more, compared with patients with ACS in the absence of type 2 diabetes (p<0.05). In the presence of comorbid type 2 diabetes, the average number of hemodynamically significant affected segments was 36.66% higher compared with patients with NSTEMI (p <0.05) and 25.72% higher compared with patients with STEMI but without diabetes (p>0.05). Compared with women with preserved estrogenic background, women with estrogen deficiency were significantly more likely to have severe hemodynamically significant lesions of the coronary arteries, namely: 8.5 times more frequent multivascular diffuse lesions, 2.0-2.8 times - with localization in proximal and medial segments: mainly with deep destructive changes and with signs of defects (ulceration of atherosclerotic plaques). In one third of patients NSTEMI occurred on the background of almost intact coronary arteries due to significant disorders of coronary microcirculation, which was manifested by a sl Product Description popup.authors Izhytska Nataliya Vitaliivna Bilavka Iryna V. Bashta Halyna V. Besh Dmytro I Bulak Orest V. Voitovych Maryana O. Vosukh Olena V. Halkevych Marta P. Holyk Oksana M. Demska Halyna I Zaremba Yevheniia H. Zaremba Olha V. Kapustynskyi Oleh O. Kysil Orysia Yu. Kyyak Yulian H. Klymkovych Olena Yu. Kopchak Lesya M. Kuz Nataliia R Labinska Olha Ye. Lutska Vira L. Makar Oksana R Melen Yuriy P. Myzak Yaroslav V. Obrotska Khrystyna M. Pavelko Mykhaylo M. Pylypiv Olesya S. Poltorak Ludmyla V. Prokosa Maryana I Protsko Vasyl V. Rak Nataliia O. Salo Viktor M. Svitlyk Halyna V. Skybchyk Vasyl A. Sklyarova Olena Ye. Slaba Nataliia A. Smaliukh Olha V. Solomenchuk Tetiana M. Tyshko Lidiia O. Fedechko Maryana Yo. Tshngryan Gayane V. popup.nrat_date 2020-12-02 Close