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Information × Registration Number 0220U104019, 0120U102256 , R & D reports Title Joint project: Synthesis and use of calixarene as modulators of biochemical processes and possible platforms for the creation of new drugs. Part 2. Design, Synthesis, Molecular Structure, and Physicochemical Characteristics of Calixarene Smooth Cell Energy Modulators popup.stage_title Head Kalchenko Vitalii I., Доктор хімічних наук Registration Date 03-12-2020 Organization Institute of Organic Chemistry NAS of Ukraine popup.description2 In order to expand the biological studies of chalcone-containing derivatives of tetra-tert-butyl-calix[4]aren, resynthesis of compounds with one, two, three and four chalconamide fragments on the lower rim of the macrocycle was performed, and thiacalix[4]arenes with two and four groups were synthesized. Calixarene chalconamides have been found to be in a nanoscale cone-shaped conformation that is stabilized by a system of intramolecular hydrogen bonds. Samples of synthesized (thia)calix[4]arene-chalconamides were transferred to the Palladin Institute of Biochemistry NAS of Ukraine for further biological research.  Product Description popup.authors Yesipenko Olexandr A Atamas Lyudmila I Boiko Yuriy S Vishnevskiy Sergiy G Dovgopyata Lidiya S Drapailo Andriy B Kalchenko Vitaly I Rodik Roman V Silenko Oleg M Selihova Anna I Trybrat Olexandr O Cherenok Sergiy O popup.nrat_date 2020-12-03 Close