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Information × Registration Number 0220U104071, 0118U006190 , R & D reports Title Intellectual chemosensory systems for medical diagnostics of therapeutically important amino acids and their derivatives based on calixarene-containing compounds. Section 2. Molecular design and synthesis of highly selective calixarene receptors forming supramolecular complexes with amino acids and their derivatives popup.stage_title Head Kalchenko Vitalii I., Доктор хімічних наук Registration Date 07-12-2020 Organization Institute of Organic Chemistry NAS of Ukraine popup.description2  In order to design enantioselective receptors of molecules for the creation of chemosensors, three theoretically possible isomers of propyloxy-octyloxy-calix [4] arenoacetic acid were synthesized and their absolute configuration was established. Their enantiodiscriminating properties in relation to a number of chiral compounds have been studied. A sufficiently high enantioselectivity was found when binding to (R) - and (S) -forms of 2-aminobutanol and the complexation of calix [4] arenoacetic acids with these reagents was studied in detail. Such alkyl-substituted calix [4] arenoacetic acid derivatives can be promising as enantioselective receptors for the design of chemosensors that can recognize amino acid enantiomers and peptides and low molecular weight proteins based on them in biological fluids. Product Description popup.authors Yesipenko Olexandr A Atamas Lyudmila I Boiko Yuriy S Vishnevskiy Sergiy G Dovgopyata Lidiya S Drapailo Andriy B Kalchenko Vitaly I Rodik Roman V Silenko Oleg M Selihova Anna I Trybrat Olexandr O Cherenok Sergiy O popup.nrat_date 2020-12-07 Close