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Information × Registration Number 0220U104276, 0120U104144 , R & D reports Title Design and physicochemical properties of new multicomponent nanosystems for the treatment and diagnosis of solid tumors. popup.stage_title Head Kutsevol Natalia V., Доктор хімічних наук Registration Date 15-12-2020 Organization Taras Shevchenko National University of Kyiv popup.description2 The object of research - physico-chemical processes that occur in multicomponent nanosystems during their formation and temperature change, processes in the nanosystem of polymer nanoparticles of gold under laser irradiation. The aim of the project is to create highly effective hybrid nanocomposites for photodynamic chemotherapy based on branched polymers-nanocarriers of different chemical nature, which are able to respond to external stimuli (pH, temperature). Study of physicochemical processes that occur during the formation of multicomponent nanosystems with various photosensitizers, gold nanoparticles and chemotherapeutics (doxorubicin, cisplatin) incorporated into the polymer matrix. Research methods - IR spectroscopy, transmission electron microscopy, UV-vis spectroscopy, dynamic light scattering, holographic interferometry. It has been shown that branched polymers capable of responding to an external challenge are promising platforms for the creation of nanocomposites for photodynamic antitumor therapy (PDT) and complex photodynamic chemotherapy. These nanocarriers are able to form complexes with antitumor drugs doxorubicin (Dox), cisplatin (CPt) and chlorine photosensitizers (Ce6). It is shown that the increase of hydrophobicity of the photosensitizer leads to cardinal changes in the field of physiological temperatures in the nanosystem created on the basis of thermosensitive polymer. It is proved that in the presence of gold nanoparticles (AuNF) in the polymer matrix there is a local heating in the region of metal nanoparticles, the effect does not depend on the nature of the polymer matrix and the presence of photosensitizer, which may be an additional factor (hyperthermia) in creating effective nanosystems. In vitro testing of Polymer / AuH / Ce6 nanosystems has shown that they are toxic to MT4 and MCF-7 / Dox tumor cells in PDT. This effect was significantly weaker for pre-prepared D-PAA / AuHF / Ce6 / Dox nanosystems.  Product Description popup.authors Yeshchenko Oleg А. Virych Pavlo A. Kuziv Yuliya I. Naumenko Antonina Р. Filipchenko Svitlana О. popup.nrat_date 2020-12-15 Close