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Information × Registration Number 0220U104336, 0118U000244 , R & D reports Title Biocompatible, water soluble C60 fullerenes as anti-fibrotic and anti-neoplastic agents for malignant neoplasms of the liver. popup.stage_title Head Kuznietsova Halyna M., Registration Date 16-12-2020 Organization Taras Shevchenko National University of Kyiv popup.description2 Subject of research: anti-inflammatory, antifibrotic, antitumor properties of biocompatible water-soluble unmodified C60 fullerenes and mechanisms of their realization in liver pathologies. Object of study: water-soluble biocompatible unmodified C60 fullerenes. The aim of the work is to establish the antitumor and antifibrotic action of biocompatible water-soluble C60 fullerenes in the development of liver cancer of different nature and the main mechanisms of this action. Research methods: histological, biochemical, cultural, immunocytochemical, methods of mathematical modeling and statistical analysis. C60FAS has been shown to inhibit the processes of fibrogenesis and malignant degeneration of liver tissues both during action during the processes of fibrogenesis and when administered to animals in cancer (in malignant tissues), and helps maintain functional activity of the liver, but causes renal dysfunction and negative on the pancreas. The mechanisms of action of C60 fullerenes are related to their ability to capture free radicals, which is manifested in the "normalization" of the redox state of liver tissue and its approximation to the values ​​inherent in normal cells in HepG2 cells (human hepatocarcinoma). In addition, C60 fullerenes are able to inhibit the survival of malignant cells and stimulate their apoptosis, presumably by inducing p53 expression and inhibition of glucose-6-phosphate dehydrogenase, and to affect the signaling pathways of EGFR and FGFR growth factors by inhibiting, inhibiting and inhibiting can be considered as nanocarriers for the creation of antitumor complexes for the treatment of liver cancer of various natures.  Product Description popup.authors Herhelyuk Tatiana S. Hurmach Vasyl V. Dzyubenko Natalia V. Lynchak Oksana V popup.nrat_date 2020-12-16 Close