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Information × Registration Number 0220U104369, 0120U105414 , R & D reports Title Evaluation of the potential cardioprotective effect of initial samples of graphene and native enzymes in situ popup.stage_title Head Sahach Vadym F., д.мед.н. Registration Date 16-12-2020 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  The aim of the study was to investigate the effect of the samples of nanosized graphene on myocardial contractile function of the isolated rat heart, myocardial resistance to ischemia, coronary vascular tone and oxygen consumption, with their intravenous administration as a series of new highly effective antioxidants. It was found that the original sample of unmodified graphene oxide showed a strong cardioprotective effect in the model of myocardial ischemia / reperfusion of an isolated rat heart which was manifested in the preservation of myocardial contractile function, significant increase in coronary flow and prevention of ineffective use. These data indicate the prospects for the use of graphene for the further development of anti-ischemic drugs for the correction of reperfusion disorders of myocardial function. Product Description popup.authors Goshovska Julia V Julia V. Korkach Yulia P. Mys Lidiya A. Sagach Vadym F. popup.nrat_date 2020-12-16 Close