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Information × Registration Number 0220U104404, 0120U104774 , R & D reports Title Impact of neurophysiological mechanisms of respiration on acute respiratory distress syndrome: the role of transient potential receptors (TRP),opioid (MOR) and cannabinoid (CA) receptors. popup.stage_title Head Isayev Dmytro S., Кандидат біологічних наук Registration Date 16-12-2020 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2   During the study, acute respiratory distress syndrome was simulated in SHR rats by intratracheal spraying of PolyI: C synthetic RNA with subsequent hyperventilation on a Flexivent device. Evaluation of dynamic changes in the respiratory function of the lungs of laboratory animals was performed by the method of forced oscillations using the device FlexiVent SCIREQ. The following parameters were evaluated: Newtonian resistance, tissue stiffness and elasticity, hysteresis, tissue dumping and static elongation. The severity of GRDS was assessed by the following parameters: the ratio of wet lung mass to dry lung, the number of neutrophilic granulocytes and total protein content in bronchoalveolar lavage, lung distensibility and rigidity, impedance, level of proinflammatory cytokines in lung tissue (Gro, Ill2ra, C) ultrastructural changes in lung tissues and electrophysiological indicators of vagus nerve activity. As a result, an experimental model of GRDS was developed and tested, which in its characteristics correlates with this pathology in patients with viral pneumonia. Product Description popup.authors Demchenko Sofia O. Drevytska Tetyana I. Morgachev Roman O. Savotchenko Alina V. Stefanenko Maria V. Tkachenko Yuriy M Yuriy M. popup.nrat_date 2020-12-16 Close