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Information × Registration Number 0220U104473, 0120U105116 , R & D reports Title Determine the number of NETs and extracellular DNA in the circulating blood in rats at ARDS modelling, study of the inhibitory activity of promising ligands against PKCB, evaluation of the effect of PKCB-active compounds on the induction of NETs in culture, estimation of dose-dependent effect. popup.stage_title Head Pashevin Denis О., к.мед.н. Registration Date 18-12-2020 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  During the study, acute respiratory distress syndrome (ARDS) in SHR rats was simulated by intratracheal spraying of PolyI:C synthetic RNA with subsequent hyperventilation on a Flexivent device. The severity of the course of acute respiratory syndrome was assessed by various markers: functional, macroscopic, biochemical, genetic, morphological and fluorimetric. Some indicators of lung respiratory function were determined, such as lung compliance and resistance. The number of extracellular neutrophil traps (NETs) in the circulating blood was determined. The amount of extracellular DNA in the plasma of rats was also determined. The level of proinflammatory cytokines expression cytokines (TNFalpha, interleukin 6 and 10) was evaluated. Product Description popup.authors Kozak Taisiya O. Polishchuk Valentina O. Stroy Dmitro О. popup.nrat_date 2020-12-18 Close