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Information × Registration Number 0220U104475, 0120U104951 , R & D reports Title Development of new methods to increase the expression of ATP-sensitive potassium channels of cell membranes as a powerful universal system of endogenous protection popup.stage_title Head Strutynskyi Ruslan B., Кандидат біологічних наук Registration Date 18-12-2020 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  Six potential models for inducing the expression of KCNJ8, KCNJ11, ABCC8, and ABCC9 genes encoding the Kir6.1, Kir6.2, SUR1, and SUR2 subunits of the ATP-sensitive potassium channels, respectively, were experimentally tested. Pyridoxal-5-phosphate was found to significantly increase the expression of Kir6.1 and SUR2 mRNA, and glutathione significantly increased the expression of Kir6.1 and Kir6.2 mRNA of vascular and cardiac subunits KATP channels. A model of acute 12% hypoxia is also promising for the induction of expression of cardiac KATP channels. Experiments on isolated mitochondria have shown that the use of pyridoxal-5-phosphate and glutathione inhibited Ca2+-induced opening of the mitochondrial permeability transition pore (mPTP) openings due to a decrease in its sensitivity to the inducer of its opening - calcium. Product Description popup.authors Goshovska Julia V Julia V. Korkach Yulia P. Mys Lidiya A. Sahach Vadym F. Serebrovs'ka Zoya O. Strutynska Natalia A. Strutynskyi Ruslan B. Fedichkina Raisa A Raisa A. Sharopov Bijan R. Shysh Anzhela M. Shuba Yaroslav M. popup.nrat_date 2020-12-18 Close