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Information × Registration Number 0220U104615, 0120U105181 , R & D reports Title Hybrid nanosystems for photoimmunotherapy in the optical-X-ray energy range. popup.stage_title Head Yashchuk Valerii M., д.ф.-м.н. Registration Date 23-12-2020 Organization Taras Shevchenko National University of Kyiv popup.description2  The development of nanosystems capable of efficiently absorbing X-rays and generating singlet oxygen at the expense of absorbed energy is important for increasing the effectiveness of X-ray dynamic therapy. During the reporting phase, we studied the nanosystems “hafnium oxide nanoparticles / polystyrene / chlorine e6 nanoparticles” and “silver / DNA / berberine nanoparticles”. A study of the hafnium oxide nanoparticle / polystyrene / chlorine e6 nanoparticles showed that chlorine e6 binds to PS-PPO nanoparticles in this nanosystem, while its interaction with HfO2 nanoparticles at low concentrations is either very weak or absent (although at high concentrations, as shown in the work of the co-executor, the nanosystem "nanoparticles of hafnium oxide / nanoparticles of polystyrene / chlorine e6" interacts with the model membrane as a whole). This is not an obstacle to the task set in the project, because the secondary electrons generated in hafnium nanoparticles have a long range and will reach PS-PPO nanoparticles, even if they are in solution separately from hafnium nanoparticles. On the other hand, the presence of HfO2 nanoparticles does not affect the binding of chlorin e6 to PS-PPO nanoparticles and the energy transfer from PS-PPO to chlorine e6, which is very important, because without this binding the excitation energy transfer with PPO will not be realized. chlorine e6 is one of the key links in the energy transport of the nanosystem. It was shown that the presence of HfO2 nanoparticles in the solution leads to increased X-ray luminescence of both PS-PPO nanoparticles and “PS-PPO / chlorin e6” nanosystems. Singlet oxygen has also been shown to generate singlet oxygen in the hafnium oxide nanoparticles / polystyrene / chlorine e6 nanoparticles, although the binding of chlorine e6 to PS-PPO LFs reduces the intensity of this generation. Product Description popup.authors Hrynʹ Dmytro V. Degoda Volodymyr Ya. Losytsky Mykhailo Yu. Navozenko Oleksandr M. Podust Halyna Р. popup.nrat_date 2020-12-23 Close