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Information × Registration Number 0220U104641, 0119U102365 , R & D reports Title Synthesis of new types of heterocyclic compounds involving fluoro-containing alkenes popup.stage_title Head Markitanov Yuriy M., Кандидат хімічних наук Registration Date 24-12-2020 Organization Institute of Organic Chemistry NAS of Ukraine popup.description2 New 3-(trifluoromethyl)pyrrolines and 4-(trifluoromethyl)pyrroles bearing ester, sulfonyl, sulfamide and sulfoximine group were synthesized by [3+2]-cycloaddition reactions of 3,3,3-trifluoropropene dervatives with isocyanomethylide anions, generated from ethyl isocyanoacetate and (tosylmethyl)isocyanide, correspondingly. Hydrogenation of cyclic imine moiety and dehydrogenation of trifluoromethyl pyrrolines were investigated for the preparation of pyrrolidine and pyrrole derivatives respectively. Hydrolysis of ester function of the obtained pyrroles, pyrrolines and pyrrolidines was carried out, affording heterocyclic carboxylic acids. By dehydrofluorination of bis(1,1-dihydropolyfluoroalkyl)sulfides with lithium hydroxide in morpholine medium new type of bis(enamino)sulfides - bis(polyfluoro-2-morpholino-1-en-1-yl)sulfanes were synthesized, hydrolysis and subsequent fluorination of which with morpholinosulfur trifluoride leads to the formation of novel fluorocontaining 1,4-oxathiin derivatives Product Description popup.authors Borodkin Yaroslav S. popup.nrat_date 2020-12-24 Close