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Information × Registration Number 0220U104679, 0119U103131 , R & D reports Title Development of nitrogen-containing anthraquinone derivatives with antibacterial properties popup.stage_title Head Taras Tetyana M., Кандидат хімічних наук Registration Date 24-12-2020 Organization Vasyl Stefanyk Precarpathian National University, State Higher Educational Institution popup.description2  The object of research is acid-base transformations of diazo compounds of anthraquinone derivatives, reactions of C- and N-azo compounds, methods of triazene synthesis, physicochemical research methods, virtual computer in silico and experimental in vitro biological screening of synthesized anthraquinone derivatives. Aim of the research To create a combinatorial library of compounds for the detection of hits by carrying out the reaction of N-coupling of diazo derivatives of 9,10-anthraquinone with amines of different nature, containing pharmacophore groups and are leading compounds with potential biological activity. Prepare laboratory samples of triazens, aliphatic, aromatic and heterocyclic derivatives of amines of 9,10-anraquinone series. Conduct computer screening of biological activity using PASS, QSAR, Docking programs to establish the direction of experimental biological research and identify the leader compound. To adjust the methods of synthesis of new representatives of nitrogen-containing derivatives of 9,10-anthraquinone with different pharmacophore groups, guided by the results of computer screening of biological activity to find effective substances. Research methods organic and microbiological synthesis, elemental analysis, IR, H1 NMR spectroscopy, thin layer chromatography, experimental and virtual screening of biological activity. As a result of the STR, a combinatorial library of compounds was created to detect hits by reacting the N-coupling of 9,10-anthraquinone diazo derivatives with amines of various natures that contain pharmacophore groups and are leader compounds with potential biological activity. Laboratory samples of triazens, aliphatic, aromatic and heterocyclic derivatives of amines of 9,10-anraquinone series were prepared. Computer screening of biological activity was performed using PASS, QSAR, Docking programs to establish the direction of experimental biological research and to identify the leader compound. Key words: aminoanthraqu Product Description popup.authors Lucsas Anna Vitalievna Luchkevych Yevhen R Malakhova Iryna V. Matkivskyj Mykola P Sabadakh Oksana Petrivna Shupeniuk Basil I. popup.nrat_date 2020-12-24 Close