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Information × Registration Number 0220U104691, 0118U003026 , R & D reports Title To perform the analysis of myocarditis biomarkers and to establish predictors of its transformation in dilated cardiomyopathy popup.stage_title Head Kovalenko Volodimir M., Доктор медичних наук Registration Date 24-12-2020 Organization State Institution "National Scientific Center "Institute of Cardiology named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine popup.description2 Based on a comprehensive study of immunological biomarkers and indicators of structural and functional status of the heart in patients with myocarditis for 24 months were developed mathematical models for early prediction of myocarditis unfavourable course: long-term persistence of reduced ejection fraction (EF) of the left ventricle (LV) and heart failure. Predictors of myocarditis transformation into dilated cardiomyopathy were established and include the following pathological changes detected in the 1st month from the clinical onset of the disease: antibody content to cardiomyocytes ≥3.0 units. wholesale sq; the concentration of tumor necrosis factor-α ≥10.0 pg/ml; expression of Toll-like receptors of the 4th type on monocytes ≥15 CIF; increase in the index of end-diastolic LV volume ≥110 ml/m2; indicators of longitudinal and radial global systolic LV strain ≤7.0% and ≤12.0%, respectively, and LV EF ≤ 30%; the presence of inflammatory changes in ≥6 segments of the left ventricle; the presence of delayed enhancement in ≥5 LV segments. Product Description popup.authors Gavrilenko Tetiana I Galitska Anastasia K. Kirichenko Roman M. Kozliuk Alina S. Kornienko Tetiana M. Lichman Olexandr M. Nesukay Elena H. Pidhaina Olena A. Ryzhkova Natalia O. Ryabenko Dmytro V. Titov Evgenii Yu. Titova Natalia S. Cherniuk Sergii V. Iakushko Liudmula V popup.nrat_date 2020-12-24 Close