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Information × Registration Number 0220U104779, 0116U004505 , R & D reports Title Pathology of the respiratory, cardiovascular and digestive systems in patients with obesity and diabetes: features of the pathogenesis, diagnosis and treatment popup.stage_title Head Sklyarov Yevhen Ya., Доктор медичних наук Registration Date 27-12-2020 Organization Danylo Halytsky Lviv National Medical University popup.description2  Various disorders of gallbladder emptying were found in 78.4% of patients with diabetes. The most common (39.2%) among patients with type II diabetes is gallbladder hypokinesia, which may be a risk factor for cholelithiasis. Significantly higher rates of basal and stimulated cholecystokinin concentrations were found in patients with a combination of diabetes mellitus and biliary pathology. Helicobacter pylori infection was found in 34.0% of patients with type II diabetes. The antigenic fecal test has been shown to be a convenient, reliable, and affordable method for identifying H. pylori infection in patients with type II diabetes. For the first time, a comprehensive study of metabolic and functional disorders in patients with type 2 diabetes at different stages of cardiovascular autonomic neuropathy. ECG markers of subclinical myocardial damage have been shown to be the earliest and most informative for the early diagnosis of cardiovascular autonomic neuropathy (CAN). Hyperinsulinemia, Homeostasis Model Assessment, and DLP in patients with type 2 diabetes are highly likely to correlate positively with the severity of CAN. In patients with type 2 diabetes without verified CAN, there is an increase in the concentration of hsSRP, leptin, proinflammatory cytokines TNF- , IL-6, IL-8 and anti-inflammatory cytokine IL-10. The subclinical stage of CAN is characterized by a significantly significant increase in the content of hsSRP and TNF- . The functional stage of CAN is accompanied by a more pronounced increase in hsSRP, leptin, activity of the proinflammatory cascade of the immune response. It was found for the first time that an increase in the content of inactive N-terminal fragment of BNP (NT-proBNP) in the blood of patients with type 2 diabetes may indicate a subclinical CAN. Subclinical and clinical stages of CAN are characterized by an increase in thromboxane B2 (THB2), the ratio of TXB2 / 6-keto-prostaglandin F1 (6-keto-PGF1) and a decrease in 6-keto-PGF1 in the Product Description popup.authors Ilchyshyn Oksana S. Barnett Olga Yu. Bychkov Mykola A. Bodrevych Bogdan B Bondarenko Olga O. Bochar Olesya M. Vdovychenko Valeriy I. Vervega Bohdana M. Vergun Oksana M. Hotsko Marta Yevstakhiivna Hotsko Marta Ye. Danyleychenko Inna V. Datz Ihor V. Demydova Anna L. Denisyuk Yanina S. Dunets Yuliia V. Kikhtyak Olesya P. Kapustynska Oksana S. Kvit Khrystyna B Kovalchuk Halyna I Kozlovska Khrystina Yu. Krasnyi Mykhailo R. Kutsyk Daryna Yu. Lishchuk Orysia Z. Laniush Fedir V. Makahonov Ihor O. Makar Roman D. Maksymets Tetyana A. Mytsyk Yulian O. Moskva Khrystyna A. Nagurna Yaryna V. Pasichna Iryna O. Perepelytsya Mykhailo V. Plieshanov Yevhen V. Pokrovska Natalia K. Safonova Oksana V. Serhiyenko Victoriya O. Serhiyenko Olexandr O. Skaletska Natalia M. Sklyarov Yevgen Ya. Sorochka Maria I. Suslyk Halyna I Terletska Lesya M. Tomashevsky Yarema I. Urbanovych Alina M. Faynyk Andriy F. Fedorov Yuriy V. Ferents Iryna M. Chetaykina Anna V. Yakhnytska Maryana M. popup.nrat_date 2020-12-26 Close