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Information × Registration Number 0220U104837, 0118U007362 , R & D reports Title To develop the algorithm of histological diagnostics of the lungs pathology in patients with HIV infection popup.stage_title Head Registration Date 28-12-2020 Organization State organization “National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National academy of medical sciences of Ukraine” popup.description2  Object – 634 samples from HIV-positive patients with thorax pathology. Methods – histologic, histochemical, immunohistochemical, statistical. Aim – to find out typical morphological signs of infections lesions of lung in patients with HIV infections and to create an algorithm of morphological diagnostics of such pathological processes to minimize diagnostic errors. A number of additional special methods of histological examination of biopsy, surgical and autopsy material of HIV-infected patients for diagnostic purposes were used and the levels of diagnostic parameters of each method were established. It was found that in HIV-positive patients with infectious pathology the most rational for additional use are the methods of Ziel-Nielsen, immunofluorescent and PAS-reaction with alcyan blue in order to establish the etiology of the process. The use of a set of methods of histological examination to establish the etiology of the infectious process has increased the efficiency of morphological diagnosis by 10,0 %. The "Method of immunomorphological diagnostics of tuberculosis infection" was developed, its diagnostic expediency was determined, in particular, in lesions of the broncho-pulmonary system, the use of which allows to increase the specificity of the study from 60,0 to 81,5%. Sphere of application – phthisiology, patomorphology Product Description popup.authors Zagaba Lyudmila M Kolomiychuk Lyudmyla A Kuzovkova Svitlana D Liskina Irina V Melnik Olga O Nikolaieva Olha D Rekalova Olena M. popup.nrat_date 2020-12-28 Close