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Information × Registration Number 0220U104884, 0118U003475 , R & D reports Title To study the role of immunological mechanisms of disadaptation in reducing the control of bronchial asthma popup.stage_title Head Feshchenko Yurii I., Доктор медичних наук Registration Date 30-12-2020 Organization State organization "National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National academy of medical sciences of Ukraine" popup.description2  Objects: 380 patients with bronchial asthma (BA). The aim of the work is to improve the prediction and prevention of uncontrolled asthma based on the study of the role of immunological mechanisms of maladaptation in reducing the control of this disease. Methods: general clinical, immunological, statistical. Peculiarities of changes in T- and B-cell immunity and cellular factors of natural resistance, spontaneous, activation and dexamethasone-induced apoptosis of lymphocytes were studied, and on the basis of the obtained data criteria of adaptive and immunopathological reactions in asthma were developed and a score assessment of individual risk An increase in the frequency of high risk with unsatisfactory control was determined. The forming components of controllability and uncontrollability of asthma are established and on this basis the algorithm of forecasting and prevention of uncontrolled asthma according to the anamnesis and instrumental methods of inspection is developed. The technology of predicting the uncontrolled course of asthma by determining the index of suppression of dexamethasone proliferative response of Lf to PHA was developed, which allowed to predict the loss of disease control in 25.0 % of patients, including every tenth patient with controlled asthma before clinical signs. steroid resistance. A "Method for predicting the uncontrolled course of bronchial asthma" was developed by determining the index of inhibition of activation apoptosis Lf by dexamethasone, the use of which allows to increase the accuracy of the prognosis by 64.7 % and reduce time conduction by 2-3 times. The technology of differentiation of steroid-sensitive, steroid-dependent and steroid-resistant asthma by determination of indices of induction / inhibition by two doses of dexamethasone of activating lymphocyte apoptosis has been developed. Sphere of application – pulmonology, allergology, clinical immunology Product Description popup.authors Illinsʹka Iryna F Arefʹyeva Lyudmyla V Kanarsʹkyy Oleksandr A Kuryk Lesya M Parkhomenko Nataliya V Prymushko Nataliya A Turchyna Inna P Feshchenko Yuriy I popup.nrat_date 2020-12-30 Close